Cross Carmellose Sodium

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Cros Carmellose is made by first soaking crude cellulose in sodium hydroxide, and then reacting the cellulose with sodium monochloroacetate to form sodium carboxymethyl cellulose. Excess sodium monochloroacetate slowly hydrolyzes to glycolic acid and the glycolic acid catalyzes the cross-linkage to form croscarmellose sodium. Chemically, croscarmellose sodium is the sodium salt of a cross-linked carboxymethylated cellulose. Croscarmellose sodium is an internally cross-linked sodium carboxymethylcellulose.

The cross linking reduces water solubility while still allowing the material to swell and absorb many times its weight in water. As a result, it provides superior drug dissolution and disintegration characteristics. Croscarmellose Sodium also resolves formulators concerns over long term functional stability, reduced effectiveness at high tablet hardness levels, and similar problems associated with other products. Croscarmellose Sodium is developed to enhance drug dissolution

Cross Carmellose Sodium is used in oral pharmaceutical formulations as a disintegrant for capsules, tablets and granules. In tablet formulations, Croscarmellose Sodium may be used in both direct compression and wet granulation processes

Specifications

Product Name Cross Carmellose Sodium
Chemical Formula C12H10Ca3O14,4H2O
Molecular weight 570.49 g/mol
Molecular Weight 591.27 g/Mol
pH 5.0 to 7.0
Color whiter –light gray powder

 

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